DEPTOR

Across TCGA pan-cancer cohorts, DEPTOR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DEPTOR data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DEPTOR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DEPTOR expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where DEPTOR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.849	0.701	.002	32	view →
HNSC	OS	Tertile	II,III,IV	0.915	1.000	.009	15	view →
LUAD	OS	Median	III,IV	0.670	0.226	.010	11	view →
GBM	OS	Tertile	All	0.798	0.981	.007	4	view →
CCRCC	DFS	Median	III,IV	0.800	0.560	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DEPTOR–PDAC (DFS)

Open the PDAC breakdown →