DEPTOR

Across TCGA patient cohorts, DEPTOR protein abundance is significantly associated with the protein abundance of many other proteins, with 20,445 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DEPTOR-associated proteins across cancer lineages are DEPTOR_S260, DEPTOR_S265, and DEPTOR_S279. Each is linked with DEPTOR in more than 9 cancer types. Because this analysis shows association rather than direction, both DEPTOR-to-partner and partner-to-DEPTOR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEPTOR versus DEPTOR_S260 in LSCC, with a Pearson correlation of 0.65.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPTOR→partner) and Y-score (partner→DEPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DEPTOR_S260 →	+1.084	+0.655	<.001	<.001	3	10
HNSC	DEPTOR_S265 →	+1.009	+0.589	<.001	<.001	3	10
HNSC	DEPTOR_S279 →	+1.913	+1.236	<.001	<.001	3	8
LUAD	ITSN1 →	+0.249	+0.426	<.001	<.001	3	7
LUAD	DEPTOR_S258 →	+0.967	+0.865	.001	<.001	3	7
BRCA	FYCO1 →	+0.339	+0.359	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,445 associations by consensus.

DEPTOR vs DEPTOR_S260 — LSCC

Explore this scatter interactively →