DEPTOR

Across TCGA patient cohorts, DEPTOR mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPTOR-associated genes across cancer lineages are MEK1, EGFR_pY1068, and MYH11. Each is linked with DEPTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPTOR-to-partner and partner-to-DEPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DEPTOR-low versus DEPTOR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPTOR→partner) and Y-score (partner→DEPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.535	+3.459	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.235	-3.169	.038	.019	3	1
UCEC	MYH11 →	+1.367	+3.321	.008	.009	3	1
UCEC	p21 →	+0.230	+2.459	.008	.019	3	1
UCEC	Annexin-1 →	+0.521	+2.827	.028	.035	3	1
UCEC	VHL →	-0.851	-2.000	.005	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by DEPTOR expression — UCEC

Explore this box plot interactively →