DEPTOR

Across TCGA cell cohorts, DEPTOR mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEPTOR-associated genes across cancer lineages are CPO, SAXO1, and OR4F21. Each is linked with DEPTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPTOR-to-partner and partner-to-DEPTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPO grouped by DEPTOR-low versus DEPTOR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPTOR→partner) and Y-score (partner→DEPTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPO →	+0.145	+3.514	<.001	.007	3	1
LARGE_INTESTINE	SAXO1 →	+0.053	+3.819	<.001	.001	3	1
LARGE_INTESTINE	OR4F21 →	+0.136	+2.878	<.001	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.581	+3.618	<.001	.003	3	1
LARGE_INTESTINE	RBMY1J →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	EPX →	+0.066	+3.520	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CPO by DEPTOR expression — LARGE_INTESTINE

Explore this box plot interactively →