DEPDC7

Across TCGA pan-cancer cohorts, DEPDC7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DEPDC7 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher DEPDC7 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEPDC7 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

LIHC, ESCA, and OV are the cancer types where DEPDC7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.077	0.543	.002	18	view →
ESCA	DFS	Median	All	0.045	0.533	<.001	12	view →
OV	DFS	Median	III,IV	1.000	0.366	.023	6	view →
COAD	OS	Median	II,III,IV	0.464	0.853	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DEPDC7–LIHC (DFS)

Open the LIHC breakdown →