DEPDC7

Across TCGA pan-cancer cohorts, DEPDC7 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DEPDC7’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DEPDC7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DEPDC7 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where DEPDC7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEPDC7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	−0.487	<.001	9	view →
HNSC	Female	All	+0.930	.005	6	view →
LSCC	All	All	+0.462	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DEPDC7–CCRCC

Open the CCRCC breakdown →