DEPDC7

Across TCGA cell cohorts, DEPDC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,777 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEPDC7-associated GO terms across cancer lineages are Actin filament fragmentation, Establishment or maintenance of microtubule cytoskeleton polarity, and Substrate adhesion-dependent cell spreading. Each is linked with DEPDC7 in more than 8 cancer types. Because this analysis shows association rather than direction, both DEPDC7-to-partner and partner-to-DEPDC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament fragmentation grouped by DEPDC7-low versus DEPDC7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC7→partner) and Y-score (partner→DEPDC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament fragmentation →	+0.125	+1.623	<.001	<.001	3	9
SOFT_TISSUE	Establishment or maintenance of microtubule cytoskeleton polarity →	+0.152	+1.061	.001	.003	3	8
BONE	Substrate adhesion-dependent cell spreading →	+0.138	+1.186	<.001	<.001	3	7
BONE	Actin filament severing →	+0.224	+1.616	<.001	<.001	3	7
LIVER	B cell apoptotic process →	-0.324	-1.421	.001	.001	3	7
SOFT_TISSUE	Cerebellar Purkinje cell layer formation →	-0.714	-0.833	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,777 associations by consensus.

Actin filament fragmentation by DEPDC7 expression — BONE

Explore this box plot interactively →