DEPDC5

Across TCGA patient cohorts, DEPDC5 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC5-associated genes across cancer lineages are Bak, ASNS, and Caspase-7-cleavedD198. Each is linked with DEPDC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both DEPDC5-to-partner and partner-to-DEPDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by DEPDC5-low versus DEPDC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC5→partner) and Y-score (partner→DEPDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.196	+1.678	.009	.019	3	5
UCEC	ASNS →	+0.435	+2.070	<.001	.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.497	+1.604	.005	.010	3	4
BLCA	PARP_cleaved →	+0.332	+2.182	<.001	.033	3	3
COAD	Rad50 →	-0.385	-2.798	<.001	.003	3	3
COAD	Smad4 →	+0.154	+3.169	.003	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Bak by DEPDC5 expression — UCEC

Explore this box plot interactively →