DENR

Across TCGA pan-cancer cohorts, DENR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DENR data layer compared with 28 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DENR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DENR expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where DENR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.711	0.992	.001	60	view →
COAD	DFS	Median	All	1.000	0.914	.008	54	view →
LUAD	OS	Quartile	All	0.499	0.888	.012	7	view →
PDAC	DFS	Quartile	All	0.661	0.398	.044	4	view →
GBM	OS	Quartile	All	0.452	0.597	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DENR–CCRCC (OS)

Open the CCRCC breakdown →