DENR

Across TCGA patient cohorts, DENR mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENR-associated genes across cancer lineages are Fibronectin, RAD51, and ATM. Each is linked with DENR in more than 1 cancer types. Because this analysis shows association rather than direction, both DENR-to-partner and partner-to-DENR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by DENR-low versus DENR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENR→partner) and Y-score (partner→DENR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.429	-3.160	.018	.019	3	1
UCEC	RAD51 →	-0.164	-3.169	.032	.020	3	1
UCEC	ATM →	-0.777	-2.986	.001	.035	3	1
UCEC	p27_pT198 →	+0.119	+3.169	.043	.020	2	1
UCEC	Annexin-1 →	+0.919	+2.827	.001	.035	2	1
UCEC	eIF4E →	+0.232	+3.169	.045	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Fibronectin by DENR expression — UCEC

Explore this box plot interactively →