DENR

Across TCGA cell cohorts, DENR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,900 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DENR-associated GO terms across cancer lineages are Translation reinitiation, Transcription elongation-coupled chromatin remodeling, and DNA integrity checkpoint signaling. Each is linked with DENR in more than 19 cancer types. Because this analysis shows association rather than direction, both DENR-to-partner and partner-to-DENR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translation reinitiation grouped by DENR-low versus DENR-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENR→partner) and Y-score (partner→DENR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Translation reinitiation →	+0.098	+0.931	<.001	<.001	3	20
BONE	Transcription elongation-coupled chromatin remodeling →	+0.118	+0.493	<.001	<.001	3	15
BONE	DNA integrity checkpoint signaling →	+0.082	+0.446	.007	.001	3	14
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.075	+0.489	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.085	+1.014	<.001	.003	3	13
BONE	Centriole replication →	+0.122	+0.446	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,900 associations by consensus.

Translation reinitiation by DENR expression — OESOPHAGUS

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