DENND6A

Across TCGA pan-cancer cohorts, DENND6A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DENND6A data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DENND6A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DENND6A expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where DENND6A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.266	0.798	.020	6	view →
LSCC	OS	Median	All	0.815	0.936	.010	5	view →
HNSC	OS	Quartile	All	0.600	0.800	.031	4	view →
PDAC	DFS	Median	III,IV	0.333	0.788	.027	3	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.185	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DENND6A–LUAD (OS)

Open the LUAD breakdown →