DENND6A

Across TCGA patient cohorts, DENND6A RNA expression is significantly associated with the protein abundance of many other proteins, with 14,979 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DENND6A-associated proteins across cancer lineages are QRICH1, MRPL47, and OXA1L. Each is linked with DENND6A in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND6A-to-partner and partner-to-DENND6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND6A versus QRICH1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6A→partner) and Y-score (partner→DENND6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	QRICH1 →	+0.260	+0.360	<.001	<.001	3	6
LUAD	MRPL47 →	-0.350	-0.322	.001	<.001	3	5
PDAC	OXA1L →	-0.471	-0.276	.004	.003	3	5
PDAC	ALG5 →	-0.396	-0.294	<.001	.001	3	5
PDAC	TMED9 →	-0.531	-0.419	<.001	<.001	3	4
CCRCC	PI16 →	+0.605	+0.367	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,979 associations by consensus.

DENND6A vs QRICH1 — GBM

Explore this scatter interactively →