DENND6A

Across TCGA patient cohorts, DENND6A protein abundance is significantly associated with the RNA expression of many other genes, with 4,451 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND6A-associated genes across cancer lineages are PSMD6, PDE12, and OGN. Each is linked with DENND6A in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND6A-to-partner and partner-to-DENND6A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND6A versus PSMD6 in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6A→partner) and Y-score (partner→DENND6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PSMD6 →	+0.390	+0.205	<.001	<.001	3	4
BRCA	PDE12 →	+0.430	+0.194	<.001	<.001	3	4
CCRCC	OGN →	+0.953	+0.147	<.001	<.001	3	4
BRCA	SHQ1 →	+0.425	+0.213	<.001	<.001	3	3
BRCA	APPL1 →	+0.659	+0.219	<.001	<.001	3	3
OV	THOC7 →	+0.419	+0.203	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,451 associations by consensus.

DENND6A vs PSMD6 — BRCA

Explore this scatter interactively →