DENND6A

Across TCGA cell cohorts, DENND6A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,033 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DENND6A-associated GO terms across cancer lineages are Regulation of chromosome segregation, Positive regulation of double-strand break repair, and Protein localization to heterochromatin. Each is linked with DENND6A in more than 15 cancer types. Because this analysis shows association rather than direction, both DENND6A-to-partner and partner-to-DENND6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome segregation grouped by DENND6A-low versus DENND6A-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6A→partner) and Y-score (partner→DENND6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of chromosome segregation →	+0.115	+0.897	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of double-strand break repair →	+0.070	+0.833	<.001	<.001	3	16
OESOPHAGUS	Protein localization to heterochromatin →	+0.145	+0.708	.005	<.001	2	16
BONE	Positive regulation of DNA repair →	+0.072	+0.925	.001	<.001	3	15
BONE	Regulation of DNA repair →	+0.064	+0.800	.005	.001	3	15
BREAST	Positive regulation of double-strand break repair via homologous recombination →	+0.061	+0.607	.003	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,033 associations by consensus.

Regulation of chromosome segregation by DENND6A expression — BLOOD_Lymphoma

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