DENND6A

Across TCGA cell cohorts, DENND6A mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND6A-associated genes across cancer lineages are 50869, Sabutoclax, and KRAS (G12C) Inhibitor-12. Each is linked with DENND6A in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND6A-to-partner and partner-to-DENND6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 50869 grouped by DENND6A-low versus DENND6A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6A→partner) and Y-score (partner→DENND6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	50869 →	+0.442	+2.649	.037	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.454	+2.769	.032	.040	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.557	+2.646	.025	.047	3	1
LARGE_INTESTINE	CD532 →	+0.497	+2.652	.012	.045	3	1
LARGE_INTESTINE	FTY-720 →	+0.253	+2.722	.012	.040	3	1
LARGE_INTESTINE	IAP_5620 →	+0.364	+2.649	.048	.046	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

50869 by DENND6A expression — LARGE_INTESTINE

Explore this box plot interactively →