DENND6A-DT

Across TCGA pan-cancer cohorts, DENND6A-DT RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DENND6A-DT data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher DENND6A-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DENND6A-DT expression acts as an unfavorable survival marker, although some lineages such as THCA and LUAD show a favorable association.

KICH, THCA, and LUAD are the cancer types where DENND6A-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	All	0.425	0.928	<.001	76	view →
THCA	DFS	Median	All	0.897	0.786	<.001	23	view →
LUAD	DFS	Tertile	IV	0.906	0.532	.032	16	view →
SKCM	DFS	Tertile	IV	0.040	0.636	.017	13	view →
CESC	OS	Median	IV	0.093	0.512	.020	12	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.133	.010	11	view →
KIRP	DFS	Median	III,IV	0.642	0.260	.026	10	view →
HNSC	DFS	Quartile	All	0.726	0.589	.017	10	view →
ACC	OS	Median	III,IV	0.397	0.807	.021	9	view →
LIHC	DFS	Median	All	0.410	0.593	.009	9	view →
UVM	OS	Tertile	All	0.759	0.918	.021	8	view →
READ	DFS	Tertile	III,IV	0.560	0.204	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DENND6A-DT–KICH (OS)

Open the KICH breakdown →