DENND5B

Across TCGA pan-cancer cohorts, DENND5B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DENND5B data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher DENND5B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DENND5B expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

PRAD, UCEC, and SKCM are the cancer types where DENND5B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.687	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DENND5B–PRAD (DFS)

Open the PRAD breakdown →