DENND5B

Across TCGA patient cohorts, DENND5B RNA expression is significantly associated with the protein abundance of many other proteins, with 17,125 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND5B-associated proteins across cancer lineages are DENND5B_S1076, ANXA6, and DENND5B_T1062. Each is linked with DENND5B in more than 8 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND5B versus DENND5B_S1076 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DENND5B_S1076 →	+0.930	+0.673	<.001	<.001	3	9
COAD	ANXA6 →	+0.460	+0.588	<.001	<.001	3	6
UCEC	DENND5B_T1062 →	+0.854	+0.871	<.001	<.001	3	6
LSCC	STAP2 →	-0.895	-0.741	<.001	<.001	3	6
BRCA	ANK2 →	+0.539	+0.627	<.001	<.001	3	5
HNSC	FAM83H →	-0.624	-0.657	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,125 associations by consensus.

DENND5B vs DENND5B_S1076 — LSCC

Explore this scatter interactively →