DENND5B

Across TCGA patient cohorts, DENND5B mutation is significantly associated with the RNA expression of many other genes, with 4,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND5B-associated genes across cancer lineages are RARRES2P4, FTCDNL1, and POLR3D. Each is linked with DENND5B in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RARRES2P4 grouped by DENND5B-low versus DENND5B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RARRES2P4 →	+0.152	+4.462	<.001	.001	3	3
UCEC	FTCDNL1 →	-0.483	-1.915	<.001	.004	3	3
COAD	POLR3D →	+0.467	+3.335	<.001	.005	3	3
COAD	CXCL10 →	+1.269	+3.352	.006	.005	3	3
UCEC	CKAP2L →	+0.624	+2.332	<.001	<.001	3	3
COAD	CLEC12A →	+0.577	+2.635	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,066 associations by consensus.

RARRES2P4 by DENND5B expression — READ

Explore this box plot interactively →