DENND5B

Across TCGA patient cohorts, DENND5B mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND5B-associated genes across cancer lineages are Rad50, PKC-a_pS657, and IGFBP2. Each is linked with DENND5B in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by DENND5B-low versus DENND5B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Rad50 →	-0.344	-2.974	<.001	.035	3	3
UCEC	PKC-a_pS657 →	-0.273	-1.575	.023	.017	3	3
UCEC	IGFBP2 →	-0.556	-2.584	.006	.010	3	2
COAD	Mre11 →	+0.153	+2.182	.002	.033	3	2
COAD	PDCD4 →	-0.474	-3.576	.009	.002	3	2
COAD	Tuberin →	-0.300	-2.450	.031	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Rad50 by DENND5B expression — COAD

Explore this box plot interactively →