DENND5B

Across TCGA cell cohorts, DENND5B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,353 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DENND5B-associated GO terms across cancer lineages are Serotonin secretion, Serotonin production involved in inflammatory response, and Serotonin secretion involved in inflammatory response. Each is linked with DENND5B in more than 10 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin secretion grouped by DENND5B-low versus DENND5B-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Serotonin secretion →	-1.564	-1.456	<.001	.006	3	11
OESOPHAGUS	Serotonin production involved in inflammatory response →	-1.564	-1.456	<.001	.006	3	11
OESOPHAGUS	Serotonin secretion involved in inflammatory response →	-1.564	-1.456	<.001	.006	3	11
BREAST	Transport of virus →	+0.178	+1.039	<.001	<.001	3	11
BREAST	Intracellular transport of virus →	+0.178	+1.039	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of hippo signaling →	+0.094	+1.492	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,353 associations by consensus.

Serotonin secretion by DENND5B expression — OESOPHAGUS

Explore this box plot interactively →