DENND5B

Across TCGA cell cohorts, DENND5B mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DENND5B-associated genes across cancer lineages are CCL13, PROK1, and NLRP13. Each is linked with DENND5B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL13 grouped by DENND5B-low versus DENND5B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCL13 →	+0.177	+4.643	<.001	.003	3	2
LUNG_NSCLC_LUAD	PROK1 →	+0.051	+3.736	<.001	.002	3	2
SKIN	NLRP13 →	+0.007	+3.103	.005	.004	3	2
LUNG_NSCLC_LUSC	MDFIC2 →	+0.026	+4.643	<.001	.008	3	1
LUNG_SCLC	OR5T2 →	+0.012	+4.058	<.001	.007	3	1
LUNG_SCLC	KRTAP6-1 →	+0.042	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CCL13 by DENND5B expression — CNS

Explore this box plot interactively →