DENND5B-AS1

Across TCGA pan-cancer cohorts, DENND5B-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DENND5B-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher DENND5B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DENND5B-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

MESO, OV, and ESCA are the cancer types where DENND5B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	II,III,IV	0.282	0.549	.001	69	view →
OV	DFS	Tertile	III,IV	0.427	0.315	.004	64	view →
ESCA	OS	Median	II,III,IV	0.580	0.815	<.001	49	view →
ACC	DFS	Tertile	All	0.445	0.722	.018	45	view →
READ	OS	Quartile	III,IV	0.839	0.511	.004	29	view →
COAD	DFS	Tertile	All	0.608	0.747	.010	28	view →
LGG	OS	Median	All	0.940	0.847	<.001	18	view →
SKCM	DFS	Quartile	II,III,IV	0.459	0.162	.001	14	view →
LIHC	DFS	Median	All	0.419	0.623	.007	13	view →
UCEC	DFS	Median	All	0.794	0.879	.003	12	view →
THYM	DFS	Tertile	III,IV	1.000	0.463	.042	6	view →
THCA	DFS	Quartile	II,III,IV	0.731	1.000	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DENND5B-AS1–MESO (OS)

Open the MESO breakdown →