Across TCGA pan-cancer cohorts, DENND5A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DENND5A data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DENND5A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DENND5A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where DENND5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.303	0.761	.007	19	view →
PDAC	OS	Median	IV	0.231	0.908	.010	12	view →
HNSC	DFS	Median	All	1.000	0.894	.006	11	view →
LSCC	DFS	Quartile	II,III,IV	0.778	1.000	.015	5	view →
GBM	DFS	Median	All	0.542	0.786	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: DENND5A tumor-vs-normal RNA expression · all DENND5A data types