Across TCGA patient cohorts, DENND5A RNA expression is significantly associated with the protein abundance of many other proteins, with 11,834 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DENND5A-associated proteins across cancer lineages are FSTL1, CCN1, and HTRA1. Each is linked with DENND5A in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND5A-to-partner and partner-to-DENND5A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5A→partner) and Y-score (partner→DENND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FSTL1 →	+0.868	+0.818	<.001	<.001	3	6
COAD	CCN1 →	+0.953	+0.887	<.001	<.001	3	5
COAD	HTRA1 →	+0.843	+1.026	<.001	<.001	3	5
PDAC	APOC1 →	+1.000	+0.458	<.001	<.001	3	5
OV	ITIH2 →	+0.607	+0.648	.001	<.001	3	5
COAD	LOX →	+0.750	+0.878	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,834 associations by consensus.

Exploration

DENND5A survival (RNA) · tumor vs normal (RNA) · all DENND5A data types