Across TCGA patient cohorts, DENND5A protein abundance is significantly associated with the RNA expression of many other genes, with 8,726 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND5A-associated genes across cancer lineages are TNFRSF10C, MRPL37, and VENTX. Each is linked with DENND5A in more than 4 cancer types. Because this analysis shows association rather than direction, both DENND5A-to-partner and partner-to-DENND5A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5A→partner) and Y-score (partner→DENND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TNFRSF10C →	+0.736	+0.150	<.001	.002	3	4
UCEC	MRPL37 →	-0.776	-0.394	<.001	<.001	3	4
OV	VENTX →	+0.723	+0.887	.002	.004	3	4
GBM	PLPP7 →	+0.645	+0.228	<.001	.002	2	5
LSCC	CPQ →	+0.769	+0.273	<.001	<.001	3	3
LSCC	TOMM40 →	-0.490	-0.221	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,726 associations by consensus.

Exploration

DENND5A survival (RNA) · tumor vs normal (RNA) · all DENND5A data types