Across TCGA patient cohorts, DENND5A mutation is significantly associated with the RNA expression of many other genes, with 3,769 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND5A-associated genes across cancer lineages are MRPS18C, C16orf95, and PTTG1. Each is linked with DENND5A in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND5A-to-partner and partner-to-DENND5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5A→partner) and Y-score (partner→DENND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPS18C →	+0.347	+3.237	<.001	<.001	3	4
SKCM	C16orf95 →	+0.342	+2.709	.003	.003	3	4
SKCM	PTTG1 →	+0.570	+2.508	.002	.001	3	3
CESC	MTND5P35 →	+0.023	+4.539	<.001	.008	3	3
COAD	SLC25A17 →	+0.295	+2.145	.003	.009	3	3
COAD	PSME2 →	+0.724	+3.713	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,769 associations by consensus.

Exploration

DENND5A survival (RNA) · tumor vs normal (RNA) · all DENND5A data types