Across TCGA patient cohorts, DENND5A mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND5A-associated genes across cancer lineages are ATM, GAPDH, and Caspase-7-cleavedD198. Each is linked with DENND5A in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND5A-to-partner and partner-to-DENND5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5A→partner) and Y-score (partner→DENND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.631	-2.369	<.001	<.001	3	4
UCEC	GAPDH →	+0.395	+1.241	.012	.015	3	3
COAD	Caspase-7-cleavedD198 →	+1.442	+2.708	<.001	.003	3	3
UCEC	EGFR_pY1068 →	-0.261	-2.099	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.190	-1.624	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.105	-1.349	.016	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

DENND5A survival (RNA) · tumor vs normal (RNA) · all DENND5A data types