Across TCGA cell cohorts, DENND5A mutation is significantly associated with the RNA expression of many other genes, with 960 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND5A-associated genes across cancer lineages are TMEM114, KDELR3, and RPL3. Each is linked with DENND5A in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND5A-to-partner and partner-to-DENND5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5A→partner) and Y-score (partner→DENND5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1
LARGE_INTESTINE	KDELR3 →	+1.282	+3.321	<.001	.003	3	1
LARGE_INTESTINE	RPL3 →	+0.599	+3.389	<.001	.001	3	1
LARGE_INTESTINE	TNRC6B →	+0.782	+3.234	<.001	.004	3	1
LARGE_INTESTINE	SLC25A17 →	+0.529	+2.502	.006	.005	3	1
LARGE_INTESTINE	DDHD1 →	+0.694	+2.502	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 960 associations by consensus.

Exploration

DENND5A survival (RNA) · tumor vs normal (RNA) · all DENND5A data types