Across TCGA pan-cancer cohorts, DENND4B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DENND4B data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DENND4B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DENND4B expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where DENND4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.720	0.924	.007	13	view →
HNSC	OS	Tertile	IV	0.934	0.668	.004	9	view →
CCRCC	DFS	Quartile	All	0.887	0.549	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DENND4B tumor-vs-normal RNA expression · all DENND4B data types