Across TCGA patient cohorts, DENND4B RNA expression is significantly associated with the RNA expression of many other genes, with 19,708 significant associations in total. ACC shows the largest number of these associations.

The most reproducible DENND4B-associated genes across cancer lineages are PRRC2A, ZSWIM8, and NEURL4. Each is linked with DENND4B in more than 33 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	PRRC2A →	+1.281	+0.906	<.001	<.001	3	34
DLBC	ZSWIM8 →	+1.212	+1.014	<.001	<.001	3	34
SCLC	NEURL4 →	+0.923	+0.792	<.001	<.001	3	34
SCLC	LY6G5B →	+1.667	+1.042	<.001	<.001	3	34
CHOL	NBPF15 →	+1.690	+1.252	<.001	<.001	3	34
ACC	DHX16 →	+1.114	+1.269	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,708 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types