Across TCGA patient cohorts, DENND4B RNA expression is significantly associated with the protein abundance of many other proteins, with 10,991 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DENND4B-associated proteins across cancer lineages are RPRD2, DHX9, and GATAD2B. Each is linked with DENND4B in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPRD2 →	+0.307	+0.398	<.001	<.001	3	6
GBM	DHX9 →	+0.234	+0.386	<.001	<.001	3	6
BRCA	GATAD2B →	+0.361	+0.547	<.001	<.001	3	6
BRCA	ANP32E →	+0.640	+0.461	<.001	.001	3	6
UCEC	POGZ →	+0.275	+0.645	.001	<.001	3	6
UCEC	RRP15 →	+0.359	+0.645	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,991 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types