Across TCGA patient cohorts, DENND4B protein abundance is significantly associated with the RNA expression of many other genes, with 10,320 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND4B-associated genes across cancer lineages are C1QC, CLEC4E, and FPR2. Each is linked with DENND4B in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1QC →	+1.039	+0.211	<.001	<.001	3	6
UCEC	CLEC4E →	+1.280	+0.263	<.001	<.001	3	5
PDAC	FPR2 →	+0.960	+0.212	<.001	<.001	3	5
UCEC	FGR →	+0.779	+0.270	.003	<.001	3	5
HNSC	GNLY →	+1.416	+0.237	<.001	<.001	3	5
HNSC	CD72 →	+0.987	+0.269	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,320 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types