Across TCGA patient cohorts, DENND4B mutation is significantly associated with the RNA expression of many other genes, with 5,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND4B-associated genes across cancer lineages are GEMIN2, GTSE1, and ADNP2. Each is linked with DENND4B in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GEMIN2 →	+0.426	+2.598	.007	.006	3	6
UCEC	GTSE1 →	+0.499	+1.385	<.001	.001	3	4
SKCM	ADNP2 →	+0.559	+2.604	.007	.006	3	4
SKCM	BUB3 →	+0.548	+3.396	.001	.004	3	4
UCEC	MRPS18C →	+0.267	+1.243	.001	.002	3	4
UCEC	ZWILCH →	+0.505	+2.044	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,466 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types