Across TCGA cell cohorts, DENND4B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,791 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DENND4B-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of DNA repair, and Negative regulation of gene expression, epigenetic. Each is linked with DENND4B in more than 16 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.238	+1.287	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.061	+0.992	.002	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.078	+0.881	.002	<.001	3	17
BONE	Pre-mRNA catabolic process →	+0.311	+1.486	<.001	<.001	3	16
BONE	Late viral transcription →	+0.162	+1.324	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.076	+0.851	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,791 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types