Across TCGA cell cohorts, DENND4B mutation is significantly associated with the RNA expression of many other genes, with 1,357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND4B-associated genes across cancer lineages are FAM236A, PDGFRL, and RFC5. Each is linked with DENND4B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND4B-to-partner and partner-to-DENND4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4B→partner) and Y-score (partner→DENND4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.090	+4.357	<.001	.006	3	2
BLOOD_Leukemia	PDGFRL →	+0.692	+3.199	.005	.007	3	2
BLOOD_Leukemia	RFC5 →	+0.768	+3.199	.002	.007	3	2
BLOOD_Leukemia	SGO1 →	+0.714	+3.199	.002	.007	3	2
BLOOD_Leukemia	BARD1 →	+0.861	+3.199	.001	.007	3	2
BLOOD_Leukemia	LYG1 →	+0.509	+3.318	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,357 associations by consensus.

Exploration

DENND4B survival (RNA) · tumor vs normal (RNA) · all DENND4B data types