DENND4A

Across TCGA pan-cancer cohorts, DENND4A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DENND4A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DENND4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DENND4A is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD, CCRCC, and PDAC are the cancer types where DENND4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.397	<.001	9	view →
CCRCC	Male	All	+0.377	<.001	9	view →
PDAC	Male	All	−0.818	<.001	8	view →
HNSC	All	All	+0.110	.016	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DENND4A–LUAD

Open the LUAD breakdown →