DENND3

Across TCGA patient cohorts, DENND3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,392 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND3-associated proteins across cancer lineages are APBB1IP, MYO1F, and NCF1. Each is linked with DENND3 in more than 8 cancer types. Because this analysis shows association rather than direction, both DENND3-to-partner and partner-to-DENND3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND3 versus APBB1IP in GBM, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND3→partner) and Y-score (partner→DENND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APBB1IP →	+0.731	+0.935	<.001	<.001	3	9
GBM	MYO1F →	+0.733	+0.929	<.001	<.001	3	8
GBM	NCF1 →	+0.713	+0.771	<.001	<.001	3	8
GBM	NCKAP1L →	+0.748	+0.970	<.001	<.001	3	8
GBM	ARHGAP15 →	+0.650	+0.703	<.001	<.001	3	8
LSCC	ARHGAP25 →	+0.568	+0.659	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,392 associations by consensus.

DENND3 vs APBB1IP — GBM

Explore this scatter interactively →