DENND3

Across TCGA patient cohorts, DENND3 protein abundance is significantly associated with the RNA expression of many other genes, with 19,978 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND3-associated genes across cancer lineages are SIGLEC9, LAPTM5, and TNFSF13B. Each is linked with DENND3 in more than 8 cancer types. Because this analysis shows association rather than direction, both DENND3-to-partner and partner-to-DENND3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND3 versus SIGLEC9 in GBM, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND3→partner) and Y-score (partner→DENND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC9 →	+1.175	+0.611	<.001	<.001	3	9
OV	LAPTM5 →	+1.406	+0.660	.003	.002	3	9
COAD	TNFSF13B →	+0.949	+0.257	<.001	<.001	3	8
OV	HAVCR2 →	+1.225	+0.660	.001	.002	3	8
HNSC	ITGAX →	+0.956	+0.427	<.001	<.001	3	8
GBM	SIGLEC10 →	+1.357	+0.565	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,978 associations by consensus.

DENND3 vs SIGLEC9 — GBM

Explore this scatter interactively →