DENND3

Across TCGA patient cohorts, DENND3 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND3-associated genes across cancer lineages are TIGAR, eEF2, and PKC-a_pS657. Each is linked with DENND3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND3-to-partner and partner-to-DENND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by DENND3-low versus DENND3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND3→partner) and Y-score (partner→DENND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TIGAR →	+0.387	+3.321	.020	.009	3	4
STAD	eEF2 →	+0.284	+2.700	.020	.005	3	3
STAD	PKC-a_pS657 →	-0.304	-3.000	.047	.034	3	3
UCEC	mTOR_pS2448 →	-0.104	-1.649	.011	.009	3	3
STAD	FOXO3a_pS318_S321 →	-0.239	-3.321	.001	.008	3	2
STAD	p90 RSK →	+0.321	+2.459	.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

TIGAR by DENND3 expression — STAD

Explore this box plot interactively →