DENND3

Across TCGA cell cohorts, DENND3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,337 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DENND3-associated GO terms across cancer lineages are Regulation of cytokine-mediated signaling pathway, Cytoplasmic pattern recognition receptor signaling pathway, and Regulation of Rab protein signal transduction. Each is linked with DENND3 in more than 13 cancer types. Because this analysis shows association rather than direction, both DENND3-to-partner and partner-to-DENND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytokine-mediated signaling pathway grouped by DENND3-low versus DENND3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND3→partner) and Y-score (partner→DENND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of cytokine-mediated signaling pathway →	+0.073	+1.450	.002	<.001	3	14
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.072	+1.913	<.001	<.001	3	13
LUNG_SCLC	Regulation of Rab protein signal transduction →	+0.112	+1.496	<.001	<.001	3	12
PANCREAS	Regulation of response to cytokine stimulus →	+0.065	+1.166	.003	.005	3	12
LARGE_INTESTINE	Positive regulation of intracellular protein transport →	+0.068	+1.034	<.001	.001	3	12
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.047	+1.319	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,337 associations by consensus.

Regulation of cytokine-mediated signaling pathway by DENND3 expression — PANCREAS

Explore this box plot interactively →