DENND2D

Across TCGA pan-cancer cohorts, DENND2D Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DENND2D data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher DENND2D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DENND2D expression acts as an unfavorable survival marker.

CESC, LGG, and UCEC are the cancer types where DENND2D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.178	0.800	<.001	18	view →
LGG	OS	Median	All	0.240	0.830	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DENND2D–CESC (OS)

Open the CESC breakdown →