DENND2D

Across TCGA pan-cancer cohorts, DENND2D mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DENND2D data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DENND2D mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND2D expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and GBM are the cancer types where DENND2D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.895	.033	18	view →
HNSC	OS	Tertile	All	0.796	0.612	.025	5	view →
GBM	OS	Median	All	0.631	0.268	.009	5	view →
LUAD	DFS	Median	All	0.730	0.520	.023	3	view →
UCEC	OS	Median	All	1.000	0.904	.007	2	view →
CCRCC	DFS	Tertile	All	0.849	0.691	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DENND2D–COAD (DFS)

Open the COAD breakdown →