DENND2D

Across TCGA patient cohorts, DENND2D RNA expression is significantly associated with the protein abundance of many other proteins, with 18,104 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND2D-associated proteins across cancer lineages are PSMB10, UBA7, and LGALS9. Each is linked with DENND2D in more than 8 cancer types. Because this analysis shows association rather than direction, both DENND2D-to-partner and partner-to-DENND2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND2D versus PSMB10 in GBM, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2D→partner) and Y-score (partner→DENND2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB10 →	+0.410	+0.676	<.001	<.001	3	9
UCEC	UBA7 →	+0.450	+0.597	<.001	.001	3	8
CCRCC	LGALS9 →	+0.612	+0.571	<.001	<.001	3	8
BRCA	EVL →	+0.550	+0.629	<.001	<.001	3	7
OV	FNBP1 →	+0.381	+0.519	<.001	<.001	3	7
BRCA	PYCARD →	+0.743	+0.640	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,104 associations by consensus.

DENND2D vs PSMB10 — GBM

Explore this scatter interactively →