DENND2D

Across TCGA patient cohorts, DENND2D protein abundance is significantly associated with the RNA expression of many other genes, with 17,259 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND2D-associated genes across cancer lineages are CASC15, MEX3A, and KIF3C. Each is linked with DENND2D in more than 8 cancer types. Because this analysis shows association rather than direction, both DENND2D-to-partner and partner-to-DENND2D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND2D versus CASC15 in UCEC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2D→partner) and Y-score (partner→DENND2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CASC15 →	-0.867	-0.322	<.001	<.001	3	9
BRCA	MEX3A →	-1.251	-0.375	<.001	<.001	3	8
OV	KIF3C →	-1.084	-0.666	.002	.002	3	8
CCRCC	LOXL2 →	-1.258	-0.296	<.001	<.001	3	7
OV	SULF1 →	-1.906	-0.745	.002	.001	3	7
UCEC	TMEM158 →	-1.239	-0.424	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,259 associations by consensus.

DENND2D vs CASC15 — UCEC

Explore this scatter interactively →