DENND2D

Across TCGA patient cohorts, DENND2D mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2D-associated genes across cancer lineages are MPP, CLP, and Adipocytes. Each is linked with DENND2D in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2D-to-partner and partner-to-DENND2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by DENND2D-low versus DENND2D-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2D→partner) and Y-score (partner→DENND2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MPP →	+0.022	+5.410	.003	.005	3	1
UCEC	CLP →	-0.063	-3.044	.012	<.001	3	1
UCEC	Adipocytes →	+0.017	+1.659	.017	.028	3	1
UCEC	Erythrocytes →	+0.039	+2.656	<.001	.005	3	1
UCEC	Myocytes →	+0.032	+2.883	.014	.032	3	1
UCEC	Basophils →	+0.171	+1.906	.012	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MPP by DENND2D expression — LUAD

Explore this box plot interactively →