DENND2D

Across TCGA cell cohorts, DENND2D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,587 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DENND2D-associated GO terms across cancer lineages are IMP biosynthetic process, Positive regulation of sodium ion transport, and Serotonin production involved in inflammatory response. Each is linked with DENND2D in more than 11 cancer types. Because this analysis shows association rather than direction, both DENND2D-to-partner and partner-to-DENND2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP biosynthetic process grouped by DENND2D-low versus DENND2D-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2D→partner) and Y-score (partner→DENND2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IMP biosynthetic process →	-0.210	-2.827	.002	.003	3	12
OESOPHAGUS	Positive regulation of sodium ion transport →	+0.260	+2.370	<.001	<.001	3	10
PANCREAS	Serotonin production involved in inflammatory response →	+1.245	+2.079	.001	<.001	3	9
PANCREAS	Serotonin secretion involved in inflammatory response →	+1.245	+2.079	.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of tolerance induction dependent upon immune response →	+1.795	+2.318	<.001	.002	3	9
PANCREAS	Locomotory exploration behavior →	-0.222	-1.566	.001	.002	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,587 associations by consensus.

IMP biosynthetic process by DENND2D expression — URINARY_TRACT

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