DENND2A

Across TCGA patient cohorts, DENND2A RNA expression is significantly associated with the RNA expression of many other genes, with 18,042 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible DENND2A-associated genes across cancer lineages are NOTCH4, ROBO4, and DCHS1. Each is linked with DENND2A in more than 30 cancer types. Because this analysis shows association rather than direction, both DENND2A-to-partner and partner-to-DENND2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND2A versus NOTCH4 in ACC, with a Pearson correlation of 0.59.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2A→partner) and Y-score (partner→DENND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	NOTCH4 →	+1.231	+1.328	<.001	<.001	3	31
TGCT	ROBO4 →	+1.262	+1.554	<.001	<.001	3	30
OV	DCHS1 →	+1.497	+1.136	<.001	<.001	3	30
TGCT	ATP1B2 →	+1.851	+1.429	<.001	<.001	3	30
CHOL	ACVRL1 →	+1.191	+0.911	.001	<.001	3	30
THYM	FBXL7 →	+2.275	+1.632	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,042 associations by consensus.

DENND2A vs NOTCH4 — ACC

Explore this scatter interactively →