DENND2A

Across TCGA patient cohorts, DENND2A mutation is significantly associated with the RNA expression of many other genes, with 3,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2A-associated genes across cancer lineages are MND1, TMX2, and FEN1. Each is linked with DENND2A in more than 4 cancer types. Because this analysis shows association rather than direction, both DENND2A-to-partner and partner-to-DENND2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by DENND2A-low versus DENND2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2A→partner) and Y-score (partner→DENND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.494	+1.638	.002	.009	3	5
LUAD	TMX2 →	+0.398	+3.205	<.001	.009	3	4
UCEC	FEN1 →	+0.587	+1.576	<.001	<.001	3	4
UCEC	PPID →	+0.339	+1.617	.007	.004	3	4
UCEC	TIMM21 →	+0.299	+1.852	.005	<.001	3	4
UCEC	CDC34 →	+0.466	+2.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

MND1 by DENND2A expression — UCEC

Explore this box plot interactively →